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AC-1202 is a compound that is metabolized into 3-hydroxybutyrate in the liver. Similar to rosiglitazone, a recent Phase IIb trial in patients with mild-to-moderate Alzheimerrsquo;s disease showed no overall advantage for AC-1202-treated patients after 90 days; however, in patients who lacked the APOE epsilon;4 allele, treatment was associated with a significant cognitive (but not global) improvement compared to placebo. 183,184 Phase III trials are expected to 20 and need viagra quick in 2008. Dimebolin (dimebon, dimebone) is approved in Russia as an antihistamine, but its effects are multifarious: it also blocks calcium channels (including the NMDA receptor), inhibits cholinesterase, and prevents the opening of mitochondrial pores under pathologic conditions. 185,186 Dimebolin has been shown to protect cultured neuronal cells against amyloid-mediated cell arey aao na haider female viagra, protect mice against NMDA-mediated neurotoxicity, and enhance cognition in rats treated with a neurotoxin. 185 A Phase II trial of dimebolin recently completed in Russia demonstrated that the drug was significantly superior to placebo on measures of cognition, global impression, activities of daily living, and behavior, with an excellent safety and tolerability profile.

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This emerging class of partial agonist drugs may function by inducing signal attenuation at a single or multiple receptors. The second-generation antipsychotic (SGA) aripiprazole is a novel CNS drug with partial agonist properties.]