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Free Radic Biol Med. 2000;28(3):351-360. 214. Morris MC, Beckett LA, Scherr PA, et al.

Two important systems that have been shown to be damaged in Alzheimerrsquo;s diseasemdash;the cholinergic and glutamatergic systemsmdash;are well-characterized for their importance in learning and memory. 6,7. The cholinergic hypothesis of Alzheimerrsquo;s disease is rooted in observations that the Alzheimerrsquo;s disease brain undergoes a widespread loss of cholinergic neurons and decreased levels of the neurotransmitter acetylcholine (ACh), both of which are associated with impaired memory and cognition. 8,9 Treatment strategies utilizing cholinergic agents are based upon the assumption that enhancing cholinergic neurotransmission in the Alzheimerrsquo;s disease brain will result in maintenance or improvement of cognitive function.

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