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Genetic variation within Nalp1, an inflammasome component that regulates IL-1 production, correlated with the interstrain differences in KC and macrophage inhibitory protein 1 production. Consistent with the genetic correlation, IL-1 was shown to stimulate KC production by murine keratinocyte and fibroblast cell lines in vitro. Genetic variation within Nalp1 could contribute to interstrain differences in wound chemokine production by altering the amount of IL-1 produced. Recent evidence suggests that locally delivered local anesthetics may exert tissue-damaging effects such as chondrolysis after intraarticular injection.

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Couratier P, Lesort M, Sindou P, et al.]