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The present invention further extends to a pharmaceutical composition comprising the microemulsion and one of more active or pharmaceutical agents as described herein, wherein such pharmaceutical composition is suitable for topical application on a subject. Suitable pharmaceutical agents for use in the present invention include any water soluble solute, including, but not limited to peptides, proteins, polysaccharides, oligonucleotides, salts, sugars, nutrients, vitamins, nucleic acids minerals, acids, anti-oxidants, or any biological active compounds for administration to a subject, such as a human, animal or other mammal. The pharmaceutical agent is selected based upon the intended application or therapy, wherein the effect of the pharmaceutical agent is suitable to treat a particular condition. Suitable peptides and proteins that can be delivered via the microemulsion of the present invention include molecules, protein chimeric molecules, other chimeric molecules or fragments selected from the TNF superfamily (including TNF-╬, TNFRl, TNFR2, BAFF, BAFFR, OX-40, Lymphotoxin-╬, Fas-ligand); chemokines (including MCP-I, MIP-Ia, MIP-Ib 3 RANTES, IL-8 and viral like chemokine antagonist MC148); interleukins, interleukin receptors and antagonist (including IL-Ia IL-Ib 5 IL-2, IL-3, IL-4, IL-5, IL-6, IL- 7, IL-8, IL-10, IL-I l 5 IL-12, IL-13, IL-15, IL-16, IL-18, IL-20, IL-21, IL-22, IL-23, IL-24, IL-25, IL-26, IL-27, IL-28, IL-29, IL-30, their respective receptors including IL-IRa, IL- 2Ra, IL-2Rb, IL-2Rg, IL-3Ra, IL-4Ra, IL-5Ra, IL-6Ra, IL-7Ra, IL-IORa, IL-I lRa, IL- 13Ra 5 IL-15Ra as well as IL-IR Antagonist); the interferon family (including IFN-a2B, IFN-bl, IFN-g, IFN-y, IFN-aR2, IFN-aRa, IFN-aRb, IFN-gRa, IFN-gRb); lectins (including CD209 type I and II, E-Selectin, L-Selectin 5 P-Selectin, Langerin, DC-SIGN); growth factors and their receptors (including Amphiregulin, Angiopoietin, BDNF, beta-cellulin, BMPs (including BMP-2, BMP-4, BMP-7), CNTF, cripto, ECGF-I 5 EGF 5 EGFR 5 EPO 5 FGFs and their receptors (including FGF-I 5 FGF-2, FGF-5, FGF-7, FGF-9, FGF-11, FGF- 12, FGF-13, FGF-14, FGF-14 FLAG 5 FGF-18, FGF-19, FGF-21, FGFRl 5 FGFRl, FGFR4, FGFR5), Flt3-Ligand and its receptor (including Flt3) 5 G-CSF, GDNF, GM-CSF, GM- CSF-R, hGH and its receptor (including hGHR), IGF-I, IGFBP-3, M-CSF, Neuregulin, NGFs and its receptor (including NGF-b, NGFR, NGFR), NT-3 5 PDGFs 5 TGFs and their receptors (including TGF-a, TGF-b, TGFbR2) 5 Trk-A, Trk-BTPO, VEGFs and their receptors (including VEGF-A 5 VEGF-B 5 VEGF-C 5 VEGF-D 5 VEGF-165, VEGFR); embryonic growth factors (such as Noggin, Nodal, SCF 5 Wnts, Wnt-2, Wnt-3, Wnt-3A, Wnt-4, Wnt-5A, Wnt-5 A-FLAG-C 5 Wnt-5B 5 Wnt-6 5 Wnt-7A 5 Wnt-7B 5 Wnt-IOA, Wnt- 10B 5 Wnt-1 OB-FLAG-C, Wnt-11); adhesion molecules (such as adiponectin, ICAM) 5 other cytokines and proteins, such as LIF 5 OSM 5 transferring and its receptor, hormones (such as insulin, calcitonin, adrenocorticotropin (ACTH), glucagon, somatostatin, somatotropin, thymosin, parathyroid hormone, pigmentary hormones, somatomedin, lutenizing hormone and agonists and antagonists thereof, chorionic gonadotropin, hypothalmic releasing factors, antidiuretic hormones, vasopressin, thyroid stimulating hormone, endorphins, enkephalins, biphalin and prolactin. ); antibiotics (such as gentamycin, amikacin, neomycin, penicillin, streptomycin), enzymes (such as activin A asparaginase, adenosine deaminase, BACE-I, caspase-1, fucosyltransferase, furin, mTACE, sialyltransferase ) Factor VIII, LH-RH analogs, anticoagulants such as Heparin, Warfarin, Herbal extracts such as those derived from Danshen.

An interesting set of first-episode studies have been conducted Europe. These included a multicenter trial in first-episode patients where risperidone and haloperidol were compared using very low 2-mg doses of both.]