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2d at 1131. ¬ 17 Like the appellant in McCauley v.

Suitable biological measurements include blood levels of insulin and glucose in body fluids, tissues or organs compared to pre-treatment levels. Other measurements include, but are not limited to, body weight and blood pressure as well as ADME (absorption, distribution, metabolism and excretion) measurements. Information recorded for each patient includes age (years), gender, height (cm), family history of condition (yesno), motivation rating (somemoderategreat) and number and type of previous treatment regimens for the indicated condition.

The present invention further provides a method suitable for the transdermal delivery of active agents in a range of therapeutic, cosmetic and research applications. The method comprises (a) preparing a water phase, including dissolving one or more selected active agents in water; (b) preparing an oil phase; (c) emulsifying the water phase and the oil phase using one or more zwitterionic surfactants and one or more co-surfactants, thereby forming a topical pharmaceutical composition; and (d) applying the topical pharmaceutical composition on a subject. The microemulsion of the present invention is useful inter alia for the topical delivery of anti-inflammatory agents, such as small molecules, proteins, antibodies, Fc fusion molecules and soluble receptors; vaccines; imaging agents; anti-cancer agents, particularly anti-melanoma agents; skin lightening including whitening agents; UV blocking agents, agents to reduce or nullify nitric oxide, agents useful for the treatment of erectile dysfunction; agents for increasing local circulation, agents for the amelioration of facial and skin ageing, agents for the treatment of obesity, re-pigmentation agents; genetic molecules such as RNAi, DNA, virosomes and anti-sense RNA; and agents useful in treating muscle dystrophy.]