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Dopamine antagonists and the development of breast cancer. Arch Gen Psychiatry. 2002;59(12):1147-1154.

However, cholinesterase inhibitors (ChEIs) have consistently produced significant beneficial effects in patients with mild-to-moderate Alzheimerrsquo;s disease and were the first class of compounds to earn an approval by the United States Food and Drug Administration for the treatment of Alzheimerrsquo;s disease. Double-blind, placebo-controlled studies with ChEIs have demonstrated modest benefits on cognitive, global, functional, and behavioral outcomes relative to placebo in patients with Alzheimerrsquo;s disease. 17 Open-label extension trials suggest that the beneficial effects of ChEIs persist for up to 5 years of treatment, 18-22 although no study has definitely demonstrated that ChEIs can modify or slow disease progression over long periods of time. The three currently prescribed ChEIs, donepezil, rivastigmine, and galantamine, have demonstrated comparable efficacy in clinical trials.

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