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Preferably to account for the psychological effects of receiving treatments, the trial is conducted in a double-blinded fashion. Volunteers are randomly assigned to placebo or treatment groups. Furthermore, to prevent the doctors from being biased in treatments, they are not informed as to whether the medication they are administering is the topical pharmaceutical composition of the present invention, or a placebo. Using this randomization approach, each volunteer has the same chance of being given either the new treatment or the placebo. Volunteers receive either the topical pharmaceutical composition of the present invention, for example, a microemulsion as described above in the microemulsion formulation examples 1 to 5 wherein the active agents include one or more of the following: insulin. (final concentration of 0.

A microemulsion generally is a system comprising an oil phase, a water phase and a surfactant. Some microemulsions are quaternary systems and further comprise a co- surfactant or a co-solvent. Microemulsions differ from ordinary emulsions (or macroemulsions) in that they are thermodynamically stable and form spontaneously upon mixing.]