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The sample excluded articles drawn from the Obituaries, Index or Content sections.

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14 Results of this study demonstrated that zolpidem CR differentiates from placebo with regard to its capacity to improve sleep initiation, maintenance, and satisfaction with sleep quality over this 24-week study, without development of tolerance (Table 3).

The DNIC paradigm has evolved recently into a clinical tool and simple test and has been shown to be a predictor of post-operative pain. (5) Since pregnancy is associated with decreased pain sensitivity andor enhanced processes of pain modulation, using tests that investigate pain modulation should provide a better understanding of the pathways involved with pregnancy-induced analgesia and may help predict pain outcomes during labor and delivery. For those women delivering by cesarean section, a DNIC test performed prior to surgery along with psychosocial questionnaires and genetic tests should enable one to identify women prone to suffer severe post-cesarean pain and persistent pain. These clinical tests should allow anesthesiologists to offer not only personalized medicine to women with the promise to improve well-being and satisfaction, but also a reduction in the overall cost of perioperative and long term care due to pain and suffering.

Using this randomization approach, each volunteer has the same chance of being given either the new treatment or the placebo treatment. Volunteers presenting with, for example, cutaneous melanoma, receive either the topical pharmaceutical composition of the present invention, for example, as described above in the microemulsion formulation examples 1 to 5 wherein the active agents include one or more of the following anti-cancer agents: 5-fluorouracil, carboplatin, oxaliplatin, cis-platin, selenomethionine, chlorotoxin, L49 monoclonal antibody, MAb-LM609, antileukinate, gold-monophosphine and gold-diphosphine, pyridoxal isonicotinoyl hydrazone (PIH), amino-substituted platinum complexes, paclitaxol, defoxamine, synthetic retinoids such as tretinoin, isotretinoin, and etretinate, imiquimod (e.]