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In the Tano societies of the Caribbean islands, the largest unit of organization was led by a cacique, or chief. The caciquedoms were tributary kingdoms, with payment consisting of harvests, Tano cultural artifacts include cave paintings in several locations in the country.

286,287 Additionally, hormone replacement therapy (estrogen and progesterone) in patients with Alzheimerrsquo;s disease who were treated with ChEIs showed no added benefits in patients taking rivastigmine 288 (although greater efficacy on functional measures has been reported in patients taking tacrine 289 ). As HRT has been shown to increase the risk of ischemic stroke,290 stimulate breast cancer growth, 291 and create a slightly increased risk for probable dementia and cognitive decline in healthy postmenopausal women, 292,293 clinical testing of HRT as an adjunctive therapy for Alzheimerrsquo;s disease prevention in postmenopausal women has been discontinued. However, a Phase IIIII study is under way, designed to assess the effectiveness of transdermal HRT in improving memory and the ability to live independently in postmenopausal women with Alzheimerrsquo;s disease and other dementias. 294. Another hormonal system under investigation as a target for anti-Alzheimerrsquo;s disease therapy is the hypothalamic-pituitary-gonadal axis.

Reviewing the reasons Madsen died, a Danish government insurance agency determined in 2004 that Omniscan caused her immobility and in turn her death.]