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Furthermore, to prevent the researchers from being biased in treatments, they are not informed as to whether the treatments they are administering is a pharmaceutical composition of the present invention or a placebo formulation. Using this randomization approach, each volunteer has the same chance of being given either the topical formulation of the present invention or the placebo formulation. A standardized volume of either the topical formulation of the present invention selected from Examples 3, 4 or 5 or a placebo formulation is applied to the face of volunteers in a prescribed fashion for an appropriate period, for example, 6 weeks with biological parameters associated with the facial skin being measured at the beginning (baseline measurements before any treatment), end (after the final treatment), and at regular intervals during the study period. Such measurements include: (1) the measurement of facial skin capacitance using a suitable instrument (for example, a Corneometer CM 825; Courage Khazaka Electronic, KoIn, Germany); (2) the measurement of facial skin conductance using a suitable instrument (for example, a Skicon-200; ISBS Co.

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