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The major regulator of detumescence is norepinephrine acting via postsynaptic alpha-1 adrenergic nerves modulated by presynaptic alpha-2 receptor activity. It is for this reason that detumescence can be achieved with infusion of an alpha- adrenergic agonist, such as phenylephrine, and that erection can be achieved with an alpha-adrenergic-blocking drug, such as phentolamine. Exceptions to this rule abound, and people with severe autonomic adrenergic insufficiency do not have priapism, suggesting once again that there are alternate modulators of corporeal detumescence.

Marcinko is past Editor-in-Chief of the prestigious 8220;Journal of Health Care Finance8221;, and a former Certified Financial Planner¬ who was named 8220;Health Economist of the Year8221; in 2010, by PM magazine. He is a Federal and State court approved expert witness featured in hundreds of peer reviewed medical, business, economics and trade publications [AMA, ADA, APMA, AAOS, Physicians Practice, Investment Advisor, Physician8217;s Money Digest and MD News] etc. As a licensed insurance agent, RIA 8211; SEC registered representative, Marcinko was Founding Dean of the fiduciary and niche focused CERTIFIED MEDICAL PLANNER¬ online chartered designation education program; as well as Chief Editor of the HEALTH DICTIONARY SERIES¬ Wiki Project. Marcinko8217;s professional memberships included: ASHE, AHIMA, ACHE, ACME, ACPE, MGMA, FMMA and HIMSS. He was a MSFT Beta tester, Google Scholar, 8220;H8221; Index favorite and one of LinkedIn8217;s 8220;Top Cited Voices8221. Presently, Marcinko is 8220;ex-officio8221; and Ramp;D Scholar-on-Sabbatical for iMBA, Inc.