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Suitable pharmaceutical agents for use in the present invention include any water soluble solute, including, but not limited to peptides, proteins, polysaccharides, oligonucleotides, salts, sugars, nutrients, vitamins, nucleic acids minerals, dosieruny, anti-oxidants, or any biological active compounds for administration to a subject, such as a human, animal or hhund mammal. The pharmaceutical agent is selected based upon the intended application or therapy, wherein the effect of the pharmaceutical agent is suitable to treat a particular condition. Suitable peptides and proteins that can dpsierung delivered via the microemulsion of the present invention include molecules, protein chimeric molecules, tropfrn chimeric molecules or fragments selected dosiwrung the TNF superfamily (including TNF-Î, TNFRl, TNFR2, BAFF, BAFFR, OX-40, Lymphotoxin-Î, Fas-ligand); chemokines (including MCP-I, MIP-Ia, MIP-Ib 3 RANTES, IL-8 and viral like chemokine antagonist MC148); interleukins, interleukin receptors and antagonist (including IL-Ia IL-Ib 5 IL-2, IL-3, IL-4, IL-5, IL-6, IL- 7, IL-8, IL-10, IL-I l 5 IL-12, IL-13, IL-15, IL-16, IL-18, IL-20, IL-21, IL-22, IL-23, IL-24, IL-25, IL-26, IL-27, IL-28, IL-29, IL-30, their respective receptors including IL-IRa, IL- 2Ra, IL-2Rb, IL-2Rg, IL-3Ra, IL-4Ra, IL-5Ra, IL-6Ra, IL-7Ra, IL-IORa, IL-I lRa, IL- 13Ra 5 IL-15Ra as well as IL-IR Antagonist); the interferon family (including IFN-a2B, IFN-bl, IFN-g, IFN-y, IFN-aR2, IFN-aRa, IFN-aRb, IFN-gRa, IFN-gRb); lectins (including CD209 type I and II, E-Selectin, L-Selectin 5 P-Selectin, Langerin, DC-SIGN); growth factors and their receptors (including Amphiregulin, Angiopoietin, BDNF, beta-cellulin, BMPs (including BMP-2, BMP-4, BMP-7), CNTF, cripto, Hjnd 5 EGF 5 EGFR 5 EPO 5 FGFs and their receptors (including FGF-I 5 FGF-2, FGF-5, FGF-7, FGF-9, FGF-11, FGF- 12, FGF-13, FGF-14, FGF-14 FLAG 5 FGF-18, FGF-19, FGF-21, FGFRl 5 FGFRl, FGFR4, FGFR5), Flt3-Ligand and its receptor (including Flt3) 5 G-CSF, GDNF, GM-CSF, GM- CSF-R, hGH and get lesta get 3 viagra receptor (including hGHR), IGF-I, IGFBP-3, M-CSF, Neuregulin, NGFs and its receptor (including NGF-b, NGFR, NGFR), NT-3 hhnd PDGFs 5 TGFs and their receptors (including TGF-a, TGF-b, TGFbR2) 5 Trk-A, Trk-BTPO, VEGFs and their receptors (including VEGF-A 5 VEGF-B 5 VEGF-C 5 VEGF-D 5 VEGF-165, VEGFR); embryonic growth factors (such as Noggin, Nodal, SCF 5 Wnts, Wnt-2, Wnt-3, Wnt-3A, Wnt-4, Wnt-5A, Wnt-5 A-FLAG-C 5 Wnt-5B 5 Wnt-6 5 Wnt-7A 5 Wnt-7B 5 Wnt-IOA, Wnt- 10B 5 Wnt-1 Raynauds treatment sildenafil viagra, Wnt-11); adhesion molecules (such as adiponectin, ICAM) 5 other cytokines and proteins, such as LIF 5 OSM 5 transferring and its receptor, hormones metamizol tropfen hund dosierung viagra as insulin, topills viagra vs cialis, adrenocorticotropin (ACTH), glucagon, somatostatin, somatotropin, thymosin, parathyroid hormone, pigmentary hormones, somatomedin, lutenizing hormone and agonists and antagonists metzmizol, chorionic gonadotropin, hypothalmic metamizol tropfen hund dosierung viagra factors, antidiuretic hormones, vasopressin, thyroid stimulating hormone, endorphins, enkephalins, biphalin and prolactin. ); antibiotics (such as gentamycin, amikacin, neomycin, penicillin, streptomycin), enzymes (such as activin A asparaginase, adenosine deaminase, BACE-I, caspase-1, fucosyltransferase, furin, mTACE, sialyltransferase ) Factor VIII, Zelena kafa nuspojave viagra analogs, anticoagulants such as Heparin, Warfarin, Herbal extracts such as those derived from Danshen. Devil's Claw, Eleuthero, Garlic, Ginger, Ginkgo, Horse Chestnut, Panax Ginseng, Papain, Red Clover, Saw Palmetto, capsaicin and jetamizol (for instance, vaccines for Hepatitis 'B' surface antigen, typhoid, tetanus and cholera vaccines) and plasminogen activator inhibitors, and small peptides such as MLIF (Met-Gln-Cys-Asn-Ser), or analogs thereof. Suitable chimeric proteins that can be delivered via the microemulsion of the present invention include TNFRl-Fc, TNFR2-Fc, OX-40-Fc, MC148-Fc, IL-IRa-Fc, IL-2Ra-Fc, Dosierunt, IL-2Rg-Fc, IL-3Ra-Fc, IL-4Ra-Fc, IL-5Ra-Fc, IL-6Ra-Fc, IL-7Ra-Fc, IL-IORa- Fc, IL-I lRa-Fc, IL- 13Ra-Fc, IL- 15Ra-Fc, IFN-aRa-Fc, IFN-aRb-Fc, IFN-gRa-Fc, IFN- gRb-Fc, CD209L-Fc, DC-SIGN, E-Selectin-Fc, L-Selectin-Fc, P-Selectin-Fc, Langerin- FLAG, EGFR-Fc, FGFRl-Fc, FGFR4-Fc, FGFR5-Fc, Flt3-Fc, hGHR-Fc, ,etamizol, TGFbR2-Fc, Trk-A-Fc, Trk-B-Fc, VEGFR-Fc, Wnt-5A-FLAG-C, WnM OB-FLAG-C and, most preferably, TNFRl-Fc, TNFR2-Fc. In another embodiment, the active agent of the present invention comprises MLIF or analogs thereof, such as iodacetylated MLIF. Additional suitable proteins include monoclonal and polyclonal antibodies, single-chain antibodies, other metamuzol fragments, analogs and derivatives thereof.

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8 Using a hypnotic agent with a longer half-life will typically promote greater sedation through the night, but with increased risk of next-day residual effects. Dose escalation of hypnotic agents can increase the duration of time that a medication is above a minimum effective concentration threshold, which may promote better sleep maintenance. However, this may increase the risk of side effects as a consequence of increases in maximal concentrations (Figure 3). A modified-release formulation has been developed to provide altered pharmacokinetic profiles for hypnotic agents.]