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When it lacked therapeutic utility in schizophrenia, further study showed that buspirone in single dose had a marked taming effect on aggressive monkeys and with chronic administration reversed stress-induced behavior in several animal models of anxiety. Serotonin 5-HT 1A Receptors. Fourteen different 5-HT receptor subtypes have been unequivocally identified, divided into distinct groups depending on function. When a specific binding ligand for the 5-HT 1A receptor became available, this receptor subtype was the first of the serotonin family of receptors to be characterized.

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