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Patients with bipolar disorder seem to be more susceptible to multiple side effects of antipsychotics, not just EPS. They seem agan be potentially more vulnerable to weight gain and metabolic effects of SGAs, as well. Do any of the newer drugs carry a lowered risk of acute EPS and tardive dyskinesia.

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Precise information about the prevalence of this disorder is usually lacking, but the best estimate is approximately 0. 03; because of its late age of onset, the lifetime morbidity risk may be between 0. 05 and 0. 23 The themes of these delusions are non-bizarre, persistent, and well-circumscribed.

The longer amyloid peptide, Abeta; 1-42aggregates quickly and appears to play a critical role in the initial accumulation of plaques, 89-91 whereas Abeta; 1-40 seems to inhibit amyloid deposition in vivo. 92 Therefore, Abeta; 1-42 Abeta; 1-40 ratio may prove to be a critical parameter in the pathogenesis of Alzheimerrsquo;s disease. 93,94 Mounting evidence indicates that modulating the production or clearance of Abeta; may provide clinical benefit for patients with Alzheimerrsquo;s disease. For this reason, some current therapeutic strategies aim to inhibit APP processing into Abeta;, decrease Abeta; aggregation, or enhance Abeta; clearance from the brain.

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