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EXAMPLE 19. In vivo determination of physical and biological parameters of the skin of human subjects following topical application of a Pharmaceutical Composition with a Water-in- The individual subjects of the in vivo studies described herein are warm-blooded vertebrate animals, which include humans. A standardized volume of a topical formulation of the present invention selected from Examples 4 or 5 or a placebo formulation is applied to an appropriate area of the body, for example, the forehead or the back of the hand of volunteers in a prescribed fashion for an appropriate period, for example, 6 weeks with biological parameters associated with each skin area being measured at the beginning (baseline measurements before any treatment), end (after the final treatment), and at regular intervals during the study period. Such measurements include : (1) the measurement of skin capacitance using a suitable instrument (for example, a Corneometer CM 825; Courage Khazaka Electronic, KoIn, Germany); (2) the measurement of skin conductance using a suitable instrument (for example, a Skicon-200; ISBS Co.Hamamatsu, Japan); (3) the measurement of skin surface topography using suitable methods and instruments (for example, the generation of skin replicas of the skin area followed by analysis with a suitable instrument, for example, an optical profŌlometer, a laser profilemeter andor a transparency profŌlometer); (4) the measurement of skin surface topography using high resolution photography using a suitable instruments and software analysis (for example, the Visia System (Proctor amp; Gamble), the Primos System (GF Messtechnik GmbH, Germany), the. Leica Stereo Explorer; (5) the measurement of skin elasticity using a suitable instrument (for example, a Cutometer SEM 575 skin elasticity meter).

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