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N Engl J Med. 2003;348(14):1333-1341. McShane R, Areosa Sastre A, Minakaran N. Memantine for dementia.

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Andrew Ferguson, the state secretary of the Construction, Forestry, Mining, and Energy Union, is anxiously awaiting a reply to a request he sent to the Prime Minister last week: "RE: Union picnic day at Kirribilli House. Congratulations and well done. It is about time that an Australian prime minister had the courage to overturn the century-old and out-of-touch policy of refusing to provide Kirribilli House rent-free for special events.

58-60 It is the first available non-cholinergic Alzheimerrsquo;s disease therapy, approved for the treatment of moderate-to-severe Alzheimerrsquo;s disease in the US and Europe. A relatively long half-life (70 hours) of memantine in plasma theoretically allows for once-daily dosing, although twice-daily dosing (10 mg twice-daily) is recommended by the manufacturer. An analysis of three pooled trials in moderate-to-severe Alzheimerrsquo;s disease 62-64 showed benefits of memantine treatment over placebo on measures of cognition, global status, activities of daily living, and behavior, and pooled data of three trials in mild-to-moderate Alzheimerrsquo;s disease showed statistically significant benefits on global status and cognition. 65 Memantine is well tolerated, with a safety profile similar to that of placebo.]